Smoothies almost always have way too much sugar in them. We separate the fruit sugar from its fiber which decreases absorption time causing an insulin spike and a host of other issues that would not have been accompanied by eating the whole fruit. And we often use fruit juice in smoothies. Fruit juice is usually void of its enzymes too, but a slow juice press can solve this issue. Many of the healthier and nuttier health nuts throw in chia seeds, kale, spinach, and other great stuff, but the base is generally fruit juice which is, in fact, a refined sugar!
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